产品货号：
Z33380
中文名称：
Beclin 1/BECN1抗体
英文名称：
Anti-Beclin 1/BECN1 Antibody (Clone#2D12A3)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Beclin 1/BECN1 Antibody (Clone#2D12A3) |
| 指标别名 | ATG6;Beclin 1;beclin 1;autophagy related;beclin1;BECN1;GT197;Protein GT197;VPS30;Beclin-1 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | BECN1 |
| 克隆号 | 2D12A3 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | E.coli-derived human Beclin 1 recombinant protein (Position:M1-S354).Human Beclin 1 shares 97% amino acid (aa) sequence identity with both mouse and rat Beclin 1. |
| 实际分子量 | 52～60KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | protein G purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Beclin-1,also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene.Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K),also named Vps34,are required for the initiation of the formation of the autophagosome in autophagy.This gene participates in the regulation of autophagy and has an important role in development,tumorigenesis,and neurodegeneration.Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagywhich in turn results in increased neuronal cell death.It has been found that beclin-1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30,and in human MCF7 breast carcinoma cells. |
| Uniprot ID | Q14457 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC. |
| 基因名全称 | beclin 1,autophagy related |
| 蛋白名全称 | Beclin-1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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